IPM Microbicide Feasibility Study 
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Project Focus
Preparation for the larger Microbicides Trial

Project Location

KZN – Pietermaritzburg and Durban

Duration of Project

Preparatory stage in preparation for a bigger trial

Project Partners
Site people at the moment

Project Donors
  • IP
  • IPM
Contact Details
Mags Beksinska

Project Aim/ Objectives
  1. To describe the demographic characteristics, risk behaviour, contraceptive use, STIs, vaginal practices and use of vaginally applied products among sexually active females
  2. Provide on site GCP training experience to site staff for the trial- using vaginal microbicides
  3. Estimate detainment of future participant
  4. To estimate the incidence of pregnancy in the study population
Project Activities
The feasibility study for phase III TCM120 identified two new sites: The Dream centre and the Edendale Lay Ecumenical Centre. Meetings continue to be held with the management of both centres and agreements have been reached.

Anticipated/Actual Results
Project acceptable at sites

Additional Outputs

Future Plans
Conduct the feasibility study as planned


 Projects in the STI's & HIV Research Cluster:

  A Multi Center Acute HIV-1 Infection Prospective Observational Cohort Study
  DfiD Research Programme Consortium: Consortium for Research and Capacity Building in Reproductive and Sexual Health and HIV/AIDS in developing countries
  A Safety & Acceptability Study of a Vaginal Ring Microbicide Delivery Method for the Prevention of HIV Infection in Women (IPM011)
  Acute HIV infection (AHI) identification
  Contraceptive Research Planning Survey: Comparison of DEPO-PROVERA and IUD Pilot Study
  A phase III randomized, double blind, placebo controlled trial of acyclovir for the reduction of HIV acquisition among high risk HSV2+ HIV- individuals (HPTN039) (known locally as Thembalethu)
  Sub-study to an international multi-centre, randomised, double-blind, placebo-controlled trial to evaluate the efficacy and safety of 0.5% and 2% PRO 2000/5 gels for the prevention of vaginally acquired HPV infection
  A multi-centred randomised trial of therapeutic intervention at primary HIV-1 infection (also known as SPARTAC)
  An international multi-centre, randomised, double-blind, placebo-controlled trial to evaluate the efficacy and safety of 0.5% and 2% PRO 2000/5 gels for the prevention of vaginally acquired HIV infection
  National Research Foundation Thuthuka Programme: Developing & Advancing Excellence in Researchers
  The Safety and feasibility study of the diaphragm used with Acidform gel or KY Jelly
  Evaluation of quadrivalent HPV vaccine in reducing the incidence of anogenital warts and related genital infection in young men
  IPM Microbicide Feasibility Study
  STI/HIV Research Adherence
  STI/HIV Research HSV2 Shedding
  STI/HIV Research Gates PIP
  Focus on Men: A Programme to Improve Male Involvement in Sexual & Reproductive Health (known locally as Mpilonhle-Mpilonde)